曹林 常务副院长

曹林

教授，副主任医师，肿瘤学博士

河北一洲肿瘤医院常务副院长

北大肿瘤医院客座教授

教育经历

1986年毕业于中国人民解放军第四军医大学获医学学士学位

2003年赴英国留学深造

2007年获英国阿伯丁大学肿瘤学博士学位

2008年至2012年在美国加州大学戴维斯分校萨克拉门拖医疗中心干细胞移植中心完成博士后工作。

工作经历

在解放军309医院血液肿瘤专业副主任医师。

后任解放军309医院医疗科长、医务部副主任等职务。

2012年至2017年在英国阿伯丁大学医学研究院从事肿瘤耐药及转移机理的研究。

2010年获聘北京大学肿瘤医院客座教授。

2017年在河北一洲肿瘤医院担任常务副院长。

诊疗特长

从事临床、科研、医院管理38年，积累了丰富经验，对国内外肿瘤临床诊疗、肿瘤的发生机理、肿瘤分子诊断、耐药机理方面的进展有深入研究，尤为擅长肿瘤综合治疗。特别是在肿瘤转移及耐药的机理研究方面有较高的造诣，对肿瘤的基因特点与预后的关系有丰富经验。在国内外学术期刊发表学术论文30余篇，其中国外杂志24篇。

学术论文

· Lin Cao, Jie Liu, Jin Pu, Gillian Milne, Mei Chen, Heping Xu, Alan Shipley, John V Forrester,   Colin D McCaig, Noemi Lois, Polarized retinal pigment epithelium generates electrical signals that diminish with age and regulate retinal pathology, J Cell Mol Med 2018 Nov;22 (11): 5552-5564

· Cao L, Liu J, Pu J, Collinson JM, Forrester JV, McCaig CD, Endogenous bioelectric currents promote differentiation of the mammalian lens, J Cell Physiol. 2017 Jun 29. doi: 10.1002/jcp.26074. [Epub ahead of print]

· Yang, B., Cao, L., Liu, J., Xu, Y., Milne, G., Chan, W., Heys, SD., McCaig, CD. & Pu, J. (2015). Low expression of chloride channel accessory 1 predicts a poor prognosis in colorectal cancer. Cancer.   2015 May 15; 121(10): 1570–1580.

· Jin Pu, Lin Cao, Colin D McCaig (2015).   Physiological extracellular electrical signals guide and orient the polarity of gut epithelial cells, Tissue Barriers 02/2015; 3(3):e1037417.

· Lin Cao, Colin D McCaig, Jin Pu. Extracellular electric signals regulate neuroblast behaviours in adult brain (2015), Archives of Stem Cells & Research.

· Cao L, Pu J, Scott HR, Ching J, McCaig CD (2015).   Endogenous electrical signals in brain promote chain migration of neuroblasts through up-regulation of the purinergic receptor P2Y1. Stem Cell Rev. 2015 Feb;11(1):75-86.

· Cao L, McCaig CD, Scott HR, Zhao SW, Milne G, Clevers H, Zhao M, Pu J (2014). Polarizing intestinal epithelial cells electrically through Ror2. Journal of Cell Science. 127(Pt 15):3233-9.

· Cao L, Wei D, Reid B, Zhao S, Pu J, Pan T, Yamoah E, Zhao M (2013). Endogenous

electric currents might guide rostral migration of neuroblasts. EMBO Rep 14(2):184-

90. (This paper was highlighted as hot off the press and cover image).

·       Yang B, Cao L*, Liu B, McCaig CD, Pu J (2013). The transition from proliferation to

differentiation in colorectal cancer is regulated by the calcium activated chloride channel A1. PLoS One 8(4):e60861. (*Co-first author).

·       Vu Tran V, Zhang XD, Cao L, Li HQ, Lee BJ, Chen W, Zhao M (2013). Electrically increase transepithelial potentials -- targeting Na+/K+ pumps using synchronized electrical modulation. PLoS One 8(4):e61509.

· Zhao M, Chalmers L, Cao L, Vieira AC, Mannis M, Reid B (2012). Electrical signalling in control of ocular cell behaviors. Prog Retin Eye Res 31(1):65-88.

· Cao L, Graue-Hernandez EO, Tran V, Reid B, Pu J, Mannis MJ, Zhao M (2011).

Down-regulation of PTEN at corneal wound sites accelerates wound healing through increased cell migration. Invest Ophthalmol Vis Sci 52(5): 2272-2278.

· Cao L, Pu J, Zhao M (2011). GSK-3β is essential for physiological electric fields directed Golgi polarization. Cell Mol Life Sci 68(18):3081-93.

·       Vieira AC, Reid B, Cao L, Mannis MJ, Schwab JR, Zhao M (2011). Ionic components of electric current at rat corneal wounds. PLoS One 6(2):e17411.

·       Reid B, Vieira AC, Cao L, Mannis MJ, Schwab IR, Zhao M (2011). Specific ion fluxes generate cornea wound electric currents. Commun Integr Biol 4(4):462-5.

·       Cao L, Zhang XD, Liu X, Chen TY, Zhao M (2010). Chloride channels and transporters in human corneal epithelium. Exp Eye Res 90(6):771-9.

·       Tai G, Reid B, Cao L, Zhao M (2009). Electrotaxis and wound healing: experimental methods to study electric fields as a directional signal for cell migration. Methods

Mol Biol 571:77-97.

·        Pu J, McCaig CD, Cao L, Zhao ZQ, Segall JE, Zhao M (2007). Epidermal growth factor receptor signaling is essential for electric field directed migration of breast cancer cells. J Cell Sci 120(Pt 19):3395-403.

· 解传滨;杨涛;王子申;方春锋;徐寿平;曹林;曲宝林；质子调强放疗技术与2种光子旋转调强放疗技术在全中枢照射中的剂量学比较，医疗卫生装备 2021年05期

· 方春峰，候俊，徐寿平，杨涛，曲宝林，曹林，朱龙林，解东，继达悦；质子治疗系统原理及其应用，中国医学装备，2021年4月，第18卷第4期

· 杨涛，曲宝林，徐寿平，解传滨，徐伟，龚璇，曹林；IBA质子笔形束扫描系统束流性能验收测试，中华放射肿瘤学杂志 2020-12-15

· 杨涛,徐寿平,解传滨,龚璇,徐伟,曲宝林,王子申,方春锋,曹林；前列腺癌质子调强与光子容积旋转调强放疗计划质量评估[J].中华放射医学与防护杂志,2020,40(1):19-25

· 徐伟;杨涛;解传滨;曲宝林;曹林;王子申;宋圆圆;方春锋;徐寿平;质子点扫描技术与光子Tomotherapy在前列腺癌应用中的剂量学比较，中国医学物理学杂志2019年 第10期

科研课题（国外）

· Mechanisms of chemoresistance in solid tumours.

· Electrical control of retinal pigment epithelium and PEDF secretion: a new focus for treating age-related macular degeneration,

· The response of astrocytes to extracellular electrical signals (EES): Friend or Foe for CNS wound repair?

· Controlling Brain Tumours Electrically,

· SULSA Postdoctoral Exchange Scheme.

· A functional role for the transepithelial potential difference in cancer metastasis? -----Identification of electrically-regulated metastatic genes in breast cancer,